John,
To my knowledge, the V2 outputs a sine wave up to 350MHz, and square wave up to 960MHz. While this would allow me to use the fundamental frequency in the desired ISM band, it would still require filtering. In this case a low-pass. Given that the fundamental is 7dB higher than the 5th harmonic as would be required when using the nano V1, maybe it would be worthwhile. Other than that, I don't know how much it would simplify filter design.
But there is a potential issue with using a V2, and that's the fact that, according to the developer, phase measurements have "significant errors" when used in continuous wave mode. What the dev considers "significant", I don't know. Otherwise, V2 output is not continuous even when set to a fixed frequency. I don't know if that would actually affect my experiment, but I'd rather not base my experiment around the V2 just to find out the hard way that it doesn't work, especially since I don't see the V2 offering any significant benefit in the first place.
