I too experience this behavior using JTDX v156.? ?This began shortly after I updated Logger32 to V4.0.469.? Nothing else has changed (to my knowledge) in a while.
In the Cherry Picking Event viewer,? I see the following:? ?Note the message "JTDX did not switch to transmit".? I've verified JTDX works normally with manual activation of Txd.

Howard KD7MA