开云体育

----- Original Message -----
From: "Paul Cates" <paerca@...>
To: <FlaxSeedOil2@...>
Sent: Thursday, August 12, 2004 5:07 PM
Subject: [FlaxSeedOil2] Re: Vitamin C

OK I promised if I found it I would post it. Well here it is. I know
it has to do with fish oil, but the body converts LNA into the same
PUFA as fish oil, so eventually the paths are equal. Notice that the
addition of the chemotherapy drug cisplatin did work better with the
C and E but the omega 3 was more efficient as a cancer inhibitor with
out supplemental C and E.


Suppression of tumor growth and metastasis by dietary fish oil
combined with vitamins E and C and cisplatin.

Yam D, Peled A, Shinitzky M.

Department of Biological Chemistry, The Weizmann Institute of
Science, Rehovot, Israel.

PURPOSE: The anticancer activity of omega-3 polyunsaturated fatty
acids (omega-3 PUFA) has been shown in a large number of studies.
This study was undertaken to analyze the combined effect of omega-3
PUFA and antioxidative vitamins on the level of spontaneous
metastatic dissemination. The supportive effect of this dietary
combination on chemotherapy with cisplatin (CP) was determined in
parallel. METHODS: C57BL/6J mice bearing the Lewis lung carcinoma 3LL
were fed ad libitum one of three isocaloric diets containing 5%
soybean oil supplemented with 40 mg/kg alpha-tocopherol acetate (SO
diet), or 4% fish oil plus 1% corn oil, and basal amounts of vitamin
E (FO diet) or FO diet supplemented with vitamins E and C (FO+E+C
diet). These diets were tested in combination with the conventional
cytotoxic agent CP in a series of regimens. Tumor growth, feed
consumption, body weight, lung metastasis and lung histology were
followed. RESULTS: Both the FO dietary groups showed significantly
lower tumor development than the SO group in all examined parameters,
indicating that omega-3 PUFA have anticancer activity. However, the
FO diet, in comparison with the FO+E+C diet induced a significantly
slower rate of tumor growth, and lower metastatic load, as reflected
in lung weight. The decrease in the anticancer activity of FO by the
addition of vitamins E and C suggests that in situ oxidation of omega-
3 PUFA underlies their anticancer action. It is thus proposed that
oxidized omega-3 PUFA accumulates in the membranes and the cytosol of
tumor cells, reducing their vitality and eventually leading to their
death. No signs of anorexia or cachexia were observed in either FO
group, in contrast to the SO group. CP treatment with the SO diet had
no apparent therapeutic effect, while with the FO diets it reduced
the metastatic load. The best regimen of this combined treatment was
FO diet followed by CP treatment with FO diet supplemented with
vitamins E and C after resection of the primary growth. This regimen
could be translated to a combined therapy for human cancer.
CONCLUSIONS: Diets enriched with omega-3 PUFA may have beneficial
anticancer effects in particular when containing only basal amounts
of antioxidants such as vitamin E or C. Furthermore, the addition of
drugs which promote oxidation of omega-3 PUFA, such as ferrous salts
(e.g. as prescribed for the treatment of anemia), may further
increase these effects. However, the supportive effect of omega-3
PUFA in chemotherapy (e.g. with CP) increases when vitamins E and C
are also included.

PMID: 11221959 [PubMed - indexed for MEDLINE]






--- In FlaxSeedOil2@..., "Paul Cates" <paerca@h...> wrote:

I recently read a scientific paper on the action of Vitamin C and E
on the action of omega 3's ability to slow the growth of cancer.

It

turns out that the action of C and E inhibited omega 3's ability to
slow cancer even though they didn't know by what action. If I can
find that study again I will post it.
Paul

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